The nomination of candidate genes underlying complex traits is often focused on genetic variations that alter mRNA abundance or result in non‐conservative changes in amino acids. Although inconspicuous in complex trait analysis, genetic variants that affect splicing or RNA editing can also generate proteomic diversity and impact genetic traits. Indeed, it is known that splicing and RNA editing modulate several traits in humans and model organisms. Using high‐throughput RNA sequencing (RNA‐seq) analysis, it is now possible to integrate the genetics of (...) transcript abundance, alternative splicing (AS) and editing with the analysis of complex traits. We recently demonstrated that both AS and mRNA editing are modulated by genetic and environmental factors, and potentially engender phenotypic diversity in a genetically segregating mouse population. Therefore, the analysis of splicing and RNA editing can expand not only the regulatory landscape of transcriptome and proteome complexity, but also the repertoire of candidate genes for complex traits. (shrink)

The title of my book, Projection and Realism in Hume's Philosophy, might mislead. One might protest, with some justification, that since neither "projection" nor "realism" is Hume's term and that both carry a severe threat of anachronism, discussing them in connection with Hume is misguided. Why might the readers of this journal wish to read such a work?Well, the first thing to note is that Hume's name has come to be associated with the metaphor of projection, understood as having some (...) kind of "non-realist" connotations, and, at the same time, he attracted readings that make him a "realist" of some sort or another in different areas.1 So, there seems to be some tension here.. (shrink)

He is the darling of naturalism or the bogeyman of scepticism, a friend to virtue or an unwitting party to incipient nihilism. He is politically conservative, or a liberator from old views. He is a fideist, an advocate of faith over reason, or a precursor of Richard Dawkins.

On Buddhist metaphsical approach to suffering; a study, with some reference to George Grimm's works.

The managerial and personal approaches to Business Ethics are inadequate to address the systemic problems facing ethical reflection in Africa. It is argued that the ethical guidance position that takes the least advantaged individuals or groups in society as reference points is a more suitable ethical approach. The philosophical version of this egalitarian view as set out by John Rawls is then shortly explained, after which a few implications for Business Ethics in Africa are drawn.